abstract：PURPOSE:Postoperative stereotactic radiosurgery (SRS) has been shown to establish local control in patients with resected brain metastases, yet its efficacy may be limited, particularly for resected lesions with large post-operative resection cavities. We describe the efficacy of postoperative fractionated stereotactic...

journal_title：Journal of neuro-oncology

authors： Traylor JI,Habib A,Patel R,Muir M,Gadot R,Briere T,Yeboa DN,Li J,Rao G

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:This study evaluated an association between whole brain volume loss and neurocognitive decline following prophylactic cranial irradiation (PCI) for limited-stage small-cell lung cancer (SCLC). METHODS:This was a secondary analysis of a prospective clinical trial that accrued patients at a single instituti...

journal_title：Journal of neuro-oncology

authors： Gui C,Chintalapati N,Hales RK,Voong KR,Sair HI,Grimm J,Duhon M,Kleinberg LR,Vannorsdall TD,Redmond KJ

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:We evaluated the outcomes after stereotactic radiosurgery (SRS) for patients who developed new or progressive brain disease regardless of whether they had no prior radiation, PCI, or WBRT. METHODS:We retrospectively identified 90 SCLC patients who had SRS between 1991 and 2018. Thirty-one patients had no evide...

journal_title：Journal of neuro-oncology

authors： Faramand A,Niranjan A,Kano H,Flickinger J,Lunsford LD

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Recurrent intracranial epidermoid cysts may be difficult to address surgically given their proximity to critical neurovascular structures of the skull base. There are emerging reports of using radiotherapy (RT) for the treatment of recurrent epidermoid cysts. Here, we report a case series of adjuvant fract...

journal_title：Journal of neuro-oncology

authors： Morshed RA,Wu SY,Sneed PK,McDermott MW

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:Glioblastoma (GBM) is the most aggressive adult brain cancer, with a 15 month median survivorship attributed to the existence of treatment-refractory brain tumor initiating cells (BTICs). In order to better understand the mechanisms regulating the tumorigenic properties of this population, we studied the role o...

journal_title：Journal of neuro-oncology

authors： Vora P,Seyfrid M,Venugopal C,Qazi MA,Salim S,Isserlin R,Subapanditha M,O'Farrell E,Mahendram S,Singh M,Bakhshinyan D,Chokshi C,McFarlane N,Dvorkin-Gheva A,Brown KR,Murty N,Moffat J,Bader GD,Singh SK

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Most recent literature has confirmed the efficacy of single-session radiosurgery (sRS) in the treatment of intracranial meningioma. Unfortunately, sRS is not always applicable due to large tumor volume and the proximity of the tumor to critical structures. When sRS is not recommended, multi-session radiosurgery...

journal_title：Journal of neuro-oncology

authors： Marchetti M,Conti A,Beltramo G,Pinzi V,Pontoriero A,Tramacere I,Senger C,Pergolizzi S,Fariselli L

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Prior studies have highlighted infratentorial tumor location as a prognostic factor for solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) of the central nervous system (CNS), and spinal location is considered a positive prognostic factor for other tumors of the CNS. While SFT/HPC of the CNS is known ...

journal_title：Journal of neuro-oncology

authors： Boyett D,Kinslow CJ,Bruce SS,Sonabend AM,Rae AI,McKhann GM,Sisti MB,Bruce JN,Cheng SK,Wang TJC

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:Glioblastoma (GBM) is the most common primary brain cancer. The average survival time for the majority of patients is approximately 15 months after diagnosis. A major feature of GBM that contributes to its poor prognosis is its high invasiveness. Caveolae are plasma membrane subdomains that participate in ...

journal_title：Journal of neuro-oncology

authors： Pu W,Nassar ZD,Khabbazi S,Xie N,McMahon KA,Parton RG,Riggins GJ,Harris JM,Parat MO

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:We sought to evaluate the effectiveness of definitive or adjuvant external-beam proton therapy on local control and survival in patients with skull-base chondrosarcoma. METHODS:We reviewed the medical records of 43 patients with a median age of 49 years (range, 23-80 years) treated with double-scattered 3D ...

journal_title：Journal of neuro-oncology

authors： Holtzman AL,Rotondo RL,Rutenberg MS,Indelicato DJ,Mercado CE,Rao D,Tavanaiepour D,Morris CG,Louis D,Flampouri S,Mendenhall WM

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Although the survival of most melanoma patients diagnosed with leptomeningeal disease (LMD) is short, some patients can have better outcomes and prolonged survival. A large retrospective cohort of patients was analyzed to identify features associated with survival with LMD from melanoma. METHODS:Clinical chara...

journal_title：Journal of neuro-oncology

authors： Ferguson SD,Bindal S,Bassett RL Jr,Haydu LE,McCutcheon IE,Heimberger AB,Li J,O'Brien BJ,Guha-Thakurta N,Tetzlaff MT,Tawbi H,Davies MA,Glitza IC

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Elongation of telomeres is necessary for tumor cell immortalization and senescence escape; neoplastic cells use to alternative pathways to elongate telomeres: telomerase reactivation or a telomerase-independent mechanism termed alternative lengthening of telomeres (ALT). Telomerase and ALT pathway has been expl...

journal_title：Journal of neuro-oncology

authors： Minasi S,Baldi C,Pietsch T,Donofrio V,Pollo B,Antonelli M,Massimino M,Giangaspero F,Buttarelli FR

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Preclinical studies have suggested promising activity for the combination of disulfiram and copper (DSF/Cu) against glioblastoma (GBM) including re-sensitization to temozolomide (TMZ). A previous phase I study demonstrated the safety of combining DSF/Cu with adjuvant TMZ for newly diagnosed GBM. This phase II s...

journal_title：Journal of neuro-oncology

authors： Huang J,Chaudhary R,Cohen AL,Fink K,Goldlust S,Boockvar J,Chinnaiyan P,Wan L,Marcus S,Campian JL

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Intramedullary spinal cord metastases (ISCMs) are rare lesions affecting the spinal cord in patients with disseminated malignancy. Today, due to increased survival, these lesions are more frequently diagnosed. Literature on survival and neurologic outcomes is sparse. Herein, we describe a single institutio...

journal_title：Journal of neuro-oncology

authors： Goyal A,Yolcu Y,Kerezoudis P,Alvi MA,Krauss WE,Bydon M

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:The highly vascular malignant brain tumor glioblastoma (GBM) appears to be an ideal target for anti-angiogenic therapy; however, clinical trials to date suggest the VEGF antibody bevacizumab affects only progression-free survival. Here we analyze a group of patients with GBM who received bevacizumab treatment a...

journal_title：Journal of neuro-oncology

authors： Hovinga KE,McCrea HJ,Brennan C,Huse J,Zheng J,Esquenazi Y,Panageas KS,Tabar V

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:Intracranial glioblastomas with simultaneous spinal lesions prior to chemoradiation therapy or craniotomy, defined as initial spinal metastasis, are not well understood. Herein, we investigated intracranial glioblastoma and demonstrated the importance of spinal screening using gadolinium enhanced spinal magneti...

journal_title：Journal of neuro-oncology

authors： Shibahara I,Saito R,Osada Y,Kanamori M,Sonoda Y,Kumabe T,Mugikura S,Watanabe M,Tominaga T

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Patterns of failure in patients with olfactory neuroblastoma (ONB) according to two surgical approaches, craniofacial resection (CFR) and endoscopic surgery (ENDO), have yet to be analyzed. METHODS:We retrospectively reviewed 28 patients with surgically treated ONB between January 1995 and October 2017. F...

journal_title：Journal of neuro-oncology

authors： Kim N,Lee CG,Kim EH,Kim CH,Keum KC,Lee KS,Chang JH,Suh CO

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:There is an increasing interest in local tumor ablative treatment modalities that induce immunogenic cell death and the generation of antitumor immune responses. METHODS:We report six recurrent glioblastoma patients who were treated with intracavitary thermotherapy after coating the resection cavity wall wi...

journal_title：Journal of neuro-oncology

authors： Grauer O,Jaber M,Hess K,Weckesser M,Schwindt W,Maring S,Wölfer J,Stummer W

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Molecular data has become an essential part of the updated World Health Organization (WHO) grading of central nervous system tumors. However, stereotactic needle biopsies provide only small volume specimens and limit the extent of histologic and molecular testing that can be performed. We assessed the use of a ...

journal_title：Journal of neuro-oncology

authors： Bander ED,Jones SH,Pisapia D,Magge R,Fine H,Schwartz TH,Ramakrishna R

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Meningiomas comprise up to 30% of primary brain tumors. The majority of meningioma patients enjoy high rates of control after conventional therapies. However, patients with recurrent disease previously treated with radiotherapy have few options for salvage treatment, and systemic interventions have proven large...

journal_title：Journal of neuro-oncology

authors： Witt JS,Musunuru HB,Bayliss RA,Howard SP

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Malignant glioma is a lethal brain tumor with a low survival rate and poor prognosis. New strategies are urgently needed to augment the chemotherapeutic effects of temozolomide (TMZ), the standard drug in glioma treatment. Carnosic acid (CA) has been reported to have anticancer, antioxidant and anti-infectiou...

journal_title：Journal of neuro-oncology

authors： Shao N,Mao J,Xue L,Wang R,Zhi F,Lan Q

更新日期：2019-01-01 00:00:00

abstract：:There are two errors and one omission in the original article. Author Gottardo's correct name is Nicholas G. Gottardo, author Hulleman's correct affiliation is no. 3 (VUMC, Amsterdam), and the Acknowledgements should include the following sentence: "We would like to thank Dr Angel Montero Carcaboso (Hospital Sant Joan...

journal_title：Journal of neuro-oncology

authors： Tsoli M,Shen H,Mayoh C,Franshaw L,Ehteda A,Upton D,Carvalho D,Vinci M,Meel MH,van Vuurden D,Plessier A,Castel D,Drissi R,Farrell M,Cryan J,Crimmins D,Caird J,Pears J,Francis S,Ludlow LEA,Carai A,Mastronuzzi A,

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Gliomas are the most common cancer of the brain, with a poor prognosis in particular for glioblastoma. In 2014, a study suggested reduced survival in relation to latency of mobile phone use among glioblastoma patients. A joint epidemiological/experimental project to study effects of RF-EMF on tumor development ...

journal_title：Journal of neuro-oncology

authors： Olsson A,Bouaoun L,Auvinen A,Feychting M,Johansen C,Mathiesen T,Melin B,Lahkola A,Larjavaara S,Villegier AS,Byrnes G,Deltour I,Schüz J

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:A major challenge to developing new therapies for patients with malignant brain tumors is that relatively few small molecule anticancer drugs penetrate the blood-brain barrier (BBB) well enough to provide therapeutically effective concentrations in brain tissue before drug exposure in non-CNS tissues results in...

journal_title：Journal of neuro-oncology

authors： Ciesielski MJ,Bu Y,Munich SA,Teegarden P,Smolinski MP,Clements JL,Lau JYN,Hangauer DG,Fenstermaker RA

更新日期：2018-12-01 00:00:00

abstract：PROPOSE:To explore the value of unmeasurable enhancement pattern of residual cavity in predicting survival at early stage after gross-total resection in high-grade glioma (HGG) patients. METHODS:This retrospective study enrolled consecutive 51 HGG patients with unmeasurable enhancement who underwent gross-total resect...

journal_title：Journal of neuro-oncology

authors： Quan G,Zheng Y,Chen J,Hua B,Ji X,Zhang K,Gao D,Lei J,Yuan T

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Post-operative radiation therapy for brain metastases (BM) has become standard treatment. Concerns regarding the deleterious cognitive effects of Whole Brain Radiation Therapy spurred a trend to use focal therapies such as stereotactic radiosurgery (SRS). The purpose of this study was to prospectively evaluate ...

journal_title：Journal of neuro-oncology

authors： Berger A,Strauss I,Ben Moshe S,Corn BW,Limon D,Shtraus N,Shahar T,Kanner AA

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Macroautophagy/autophagy is considered to play key roles in tumor cell evasion of therapy and establishment of metastases in breast cancer. High expression of LC3, a residual autophagy marker, in primary breast tumors has been associated with metastatic disease and poor outcome. FIP200/Atg17, a multi-functio...

journal_title：Journal of neuro-oncology

authors： Hashemi-Sadraei N,Müller-Greven GM,Abdul-Karim FW,Ulasov I,Downs-Kelly E,Burgett ME,Lauko A,Qadan MA,Weil RJ,Ahluwalia MS,Du L,Prayson RA,Chao ST,Budd TG,Barnholtz-Sloan J,Nowacki AS,Keri RA,Gladson CL

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Prediction of clinical outcomes in patients with primary central nervous system lymphoma (PCNSL) is important for optimization of treatment planning. Quantitative imaging biomarkers for PCNSL have not yet been established. This study evaluated the prognostic value of pretreatment dynamic contrast-enhanced MRI a...

journal_title：Journal of neuro-oncology

authors： Hatzoglou V,Oh JH,Buck O,Lin X,Lee M,Shukla-Dave A,Young RJ,Peck KK,Vachha B,Holodny AI,Grommes C

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Chondroblastoma (CB) in the spine is extremely rare and there is little published information regarding this subject. We attempt to explore the clinical features of spinal CB and address the importance of total resection, especially total en bloc spondylectomy (TES) for the treatment of spinal CB. METHODS:Clin...

journal_title：Journal of neuro-oncology

authors： Jia Q,Liu C,Yang J,Ji Y,Wei H,Liu T,Yang X,Yang C,Xiao J

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:A previous study confirmed that a novel splicing variant of large vascular endothelial growth factor (L-VEGF) termed L-VEGF144, a nucleolus protein, is found in glioblastoma cells and specimens, but the actual biological function and clinical significance of L-VEGF144 remain unclear. METHODS:In this study...

journal_title：Journal of neuro-oncology

authors： Cheng WY,Shen CC,Chiao MT,Liang YJ,Mao TF,Liu BS,Chen JP

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Elevated serum alkaline phosphatase has been previously studied as a biomarker for progression of metastatic disease and implicated in adverse skeletal events and worsened survival. The purpose of this study was to determine if serum alkaline phosphatase was a predictor of short-term mortality of patients un...

journal_title：Journal of neuro-oncology

authors： Karhade AV,Thio QCBS,Ogink PT,Schwab JH

更新日期：2018-10-01 00:00:00

abstract：SUBJECT:To date there is no established tumor marker for the clinical follow-up of glioblastoma, WHO grade IV, (GBM) which constitutes the most frequent and malignant primary brain tumor. However, since there is promising data that the serum glial fibrillary acidic protein (sGFAP) may serve as a biomarker for glial bra...

journal_title：Journal of neuro-oncology

authors： Baumgarten P,Quick-Weller J,Gessler F,Wagner M,Tichy J,Forster MT,Foerch C,Seifert V,Mittelbronn M,Senft C

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:The purpose of this study is to map spatial metabolite differences across three molecular subgroups of glial tumors, defined by the IDH1/2 mutation and 1p19q-co-deletion, using magnetic resonance spectroscopy. This work reports a new MR spectroscopy based classification algorithm by applying a radiomics anal...

journal_title：Journal of neuro-oncology

authors： Diamandis E,Gabriel CPS,Würtemberger U,Guggenberger K,Urbach H,Staszewski O,Lassmann S,Schnell O,Grauvogel J,Mader I,Heiland DH

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Informal family caregivers (FCG) are an integral and crucial human component in the cancer care continuum. However, research and interventions to help alleviate documented anxiety and burden on this group is lacking. To address the absence of effective interventions, we developed the electronic Support Net...

journal_title：Journal of neuro-oncology

authors： Reblin M,Ketcher D,Forsyth P,Mendivil E,Kane L,Pok J,Meyer M,Wu YP,Agutter J

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:To evaluate the prognostic value of the Glasgow Prognostic Score (GPS), the combination of C-reactive protein (CRP) and albumin, in glioblastoma multiforme (GBM) patients treated with radiotherapy (RT) and concurrent plus adjuvant temozolomide (GPS). METHODS:Data of newly diagnosed GBM patients treated wi...

journal_title：Journal of neuro-oncology

authors： Topkan E,Selek U,Ozdemir Y,Yildirim BA,Guler OC,Ciner F,Mertsoylu H,Tufan K

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Central nervous system (CNS) involvement, especially involvement of the cerebrospinal fluid (CSF), is common in several haematological malignancies. Intrathecal (IT) chemotherapy can be used to manage CSF involvement. METHODS:Here we evaluated the effectiveness of IT chemotherapy among 80 patients with ha...

journal_title：Journal of neuro-oncology

authors： Dara A,Mook BB,Doorduijn JK,van den Bent MJ,Dinmohamed AG,Bromberg JEC

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Our primary objective was to report the current neuroimaging classification systems of spatial patterns of progression in glioblastoma. In addition, we aimed to report the terminology used to describe 'progression' and to assess the compliance with the Response Assessment in Neuro-Oncology (RANO) Criteria. ...

journal_title：Journal of neuro-oncology

authors： Piper RJ,Senthil KK,Yan JL,Price SJ

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Malignant peripheral nerve sheath tumors (MPNSTs) are rare tumors, generally high-grade, and comprise ~ 5-10% of soft tissue sarcomas. Over two-thirds of MPNSTs metastasize, and upwards of 40% clinically recur. Etiologic risk factors for MPNSTs are historically understudied. There is evidence to suggest MPNS...

journal_title：Journal of neuro-oncology

authors： Peckham-Gregory EC,Montenegro RE,Stevenson DA,Viskochil DH,Scheurer ME,Lupo PJ,Schiffman JD

更新日期：2018-08-01 00:00:00

abstract：:This study retrospectively reviewed our single institute experience to clarify the optimal indication and timing of salvage surgery. Retrospective analysis of 159 consecutive cases with germ cell tumors identified 20 cases with salvage surgery. These cases were classified based on the radiological response to neoadjuv...

journal_title：Journal of neuro-oncology

authors： Kanamori M,Kumabe T,Watanabe M,Chonan M,Saito R,Yamashita Y,Ogawa Y,Sonoda Y,Tominaga T

更新日期：2018-07-01 00:00:00

abstract：:ATP-binding cassette transporters (ABC transporters) regulate traffic of multiple compounds, including chemotherapeutic agents, through biological membranes. They are expressed by multiple cell types and have been implicated in the drug resistance of some cancer cells. Despite significant research in ABC transporters ...

journal_title：Journal of neuro-oncology

authors： Dréan A,Rosenberg S,Lejeune FX,Goli L,Nadaradjane AA,Guehennec J,Schmitt C,Verreault M,Bielle F,Mokhtari K,Sanson M,Carpentier A,Delattre JY,Idbaih A

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:This study explored the superiority of temozolomide (TMZ) + interferonβ (IFNβ) to standard TMZ as treatment for newly diagnosed glioblastoma (GBM) via randomized phase II screening design. EXPERIMENTAL DESIGN:Eligibility criteria included histologically proven GBM, with 50% of the tumor located in supratentori...

journal_title：Journal of neuro-oncology

authors： Wakabayashi T,Natsume A,Mizusawa J,Katayama H,Fukuda H,Sumi M,Nishikawa R,Narita Y,Muragaki Y,Maruyama T,Ito T,Beppu T,Nakamura H,Kayama T,Sato S,Nagane M,Mishima K,Nakasu Y,Kurisu K,Yamasaki F,Sugiyama K,Onishi

更新日期：2018-07-01 00:00:00